Relationship of virulence factor expression to evolved virulence in mouse-passaged Cryptococcus neoformans lines.
نویسندگان
چکیده
Serial passage of Cryptococcus neoformans in mice increases virulence relative to the nonpassaged line. Postpassaged lines showed no difference in the expression of most known virulence factors, with the exception that the more virulent lines had smaller capsules in vitro. These data imply that other mechanisms of virulence remain to be discovered.
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عنوان ژورنال:
- Infection and immunity
دوره 73 10 شماره
صفحات -
تاریخ انتشار 2005